D. Jeffrey Newport, Page B. Pennell, Martha R. Calamaras, James C. Ritchie, Melanee Newman, Bettina Knight, Adele C. Viguera, Joyce Liporace and Zachary N. Stowe
PEDIATRICS Vol. 122 No. 1 July 2008, pp. e223-e231
OBJECTIVE. Although lamotrigine use during pregnancy has substantially increased over the past decade secondary to accumulated reproductive safety data, systematic data on lamotrigine during breastfeeding remains sparse. We sought to characterize the determinants of lamotrigine concentrations in breast milk and nursing-infant plasma.
PATIENTS AND METHODS. Women who enrolled in a prospective investigation of perinatal medication pharmacokinetics, were treated with lamotrigine, and chose to continue lamotrigine while breastfeeding were included in the analysis.
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