Hackett LP, Ilett KF, Rampono J, Kristensen JH, Kohan R.
Eur J Clin Pharmacol. 2006 Aug;62(8):633-8. Epub 2006 May 13.

Abstract

Objective To investigate the transfer of reboxetine into milk, the absolute and relative infant doses via milk and to assess plasma concentrations and adverse unwanted effects in the breastfed infant.

Methods Multiple samples of blood and milk were obtained over a dose interval at steady-state from four women who were taking reboxetine for postnatal depression. Drug concentrations in plasma and milk were measured by high performance liquid chromatography and milk/plasma ratio (M/P), absolute infant dose and relative infant dose were estimated by standard methods.
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Katherine K. Temprano, MD, Rama Bandlamudi, MD, Terry L. Moore, MD

Semin Arthritis Rheum. 2005 Oct;35(2):112-21

OBJECTIVE: To review the toxicity issues of commonly used antirheumatic drugs in pregnancy and lactation.

METHODS: A review of the medical literature using Medline database via Ovid was performed to identify the toxicities of antirheumatic drugs in pregnancy and lactation.

RESULTS: Many rheumatologic diseases in women often first present during the childbearing years. In most cases, antirheumatic therapy is required for their disease control. Glucocorticoids may be used during pregnancy; however, first-trimester use should be avoided if possible and breastfeeding should occur 4 hours after the last dosing.
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Gerald G. Briggs, BPharm, Peter J. Ambrose, PharmD, Michael P. Nageotte, MD, Guadalupe Padilla, MD and Stephanie Wan, PharmD

Obstetrics & Gynecology 2005;105:1437-1441

(A metformin Magyarországon Adimet, Avandamet, Maformin, Meforal, Meglucon, Merckformin, Metfogamma, Metrivin neveken van forgalomban.)

OBJECTIVE: To determine whether metformin is excreted into breast milk and whether this exposure adversely affects the blood glucose of nursing infants.

METHODS: Seven women were started on metformin 500 mg twice daily on the first day after cesarean delivery. Breastfeeding was started at the same time. Two women were excluded. Two other women stopped breastfeeding for personal reasons unrelated to the drug therapy, but did provide serum and milk samples, because they regularly pumped their breasts to maintain lactation.
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WOLFGANG AICHHORN, M.D., ALEXANDRA B. WHITWORTH, M.D., ULRIKE WEISS, M.D., and CHRISTOPH STUPPAECK, M.D.
Innsbruck and Salzburg, Austria

Am J Psychiatry 161:2325, December 2004

(A mirtazapine Magyarországon Mirzaten, Mizapin és Remeron neveken van forgalomban.)

To the Editor: Postpartum depression occurs in approximately 10% of childbearing women, and for many of them, treatment with an antidepressant may be necessary. The benefit of breast-feeding for the infant and the mother is well established; clinicians are therefore asked to make a careful risk-benefit decision on the use of antidepressants. The literature on antidepressants and breast-feeding consists mainly of case series of selective serotonin reuptake inhibitors and tricyclics, whereas information on newer antidepressants is scarce (1).
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VICTORIA HENDRICK, MD; ALAN FUKUCHI, MT (ASCP); LORI ALTSHULER, MD and MEL WIDAWSKI, PhD; AMY WERTHEIMER, BA and MARTINA V. BRUNHUBER, MA
Declaration of interest This study was supported by the National Institute of Mental Health, Smith Kline Beecham and Pfizer.

The British Journal of Psychiatry (2001) 179: 163-166
ABSTRACT
Background The pharmacological treatment of depression in nursing women requires information on the magnitude of medication exposure to the infant that may occur through breast milk.

Aims To examine serum concentrations of antidepressants in infants exposed to these medications through breast-feeding.

Method Maternal and infant serum concentrations of sertraline, paroxetine and fluvoxamine were determined with high-performance liquid chromatography (limit of detection=1 ng/ml).
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