Tag Archive for: Gyógyszerek, vizsgálatok, kezelések a szoptatás időszakában

Serum Sertraline and N-Desmethylsertraline Levels in Breast-Feeding Mother-Infant Pairs

Katherine L. Wisner, M.D., James M. Perel, Ph.D., and Jeffrey Blumer, M.D., Ph.D.

Am J Psychiatry 155:690-692, May 1998

ABSTRACT
OBJECTIVE: The authors’ goal was to study the serum sertraline levels of breast-feeding mothers and their infants. METHOD: They obtained serum levels of sertraline and N-desmethylsertraline in nine mother-infant pairs. RESULTS: Sertraline levels were very low (less than 2 ng/ml) in seven of the nine infants and low (3 ng/ml) in one. N-Desmethylsertraline levels were also low (6 ng/ml or less) in seven of the nine infants. One infant had a high level of N-desmethylsertraline, and one infant had unusual serum sertraline and N-desmethylsertraline values (half of its mother’s levels).
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Serum Concentrations of Antidepressants and Benzodiazepines in Nursing Infants: A Case Series

Carol S. Birnbaum, MD, Lee S. Cohen, MD, Jennie W. Bailey, BA, Lynn R. Grush, MD, Laura M. Robertson, BA, and Zachary N. Stowe, MDDagger

PEDIATRICS Vol. 104 No. 1 July 1999, p. e11

ABSTRACT
Objective. The relative risk of psychotropic medication use in women with puerperal psychiatric illness who are breastfeeding has yet to be quantified adequately. Although the emotional and medical benefits of breastfeeding and adverse effects of maternal depression on infant development are well described, how these absolute benefits weigh against the potential effects of psychotropic drug use during lactation to ultimately guide clinical decisions is still unclear.
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Paroxetine in Human Breast Milk and Nursing Infants

Zachary N. Stowe, M.D., Lee S. Cohen, M.D., Amy Hostetter, B.A., James C. Ritchie, Ph.D., Michael J. Owens, Ph.D., and Charles B. Nemeroff, M.D., Ph.D.

Am J Psychiatry 157:185-189, February 2000

(A paroxetine Magyarországon Apodepi, Paretin, Parogen, Paroxat, Paroxetin, Rexetin, Seroxat neveken van forgalomban.)

ABSTRACT
OBJECTIVE: The purpose of this study was to determine the extent of infant medication exposure through breast-feeding during maternal treatment with paroxetine. METHOD: Breast milk and paired maternal and infant sera were collected after 10 days of maternal treatment with paroxetine at a stable daily dose (10–50 mg/day). All samples were analyzed by means of high-performance liquid chromatography with ultraviolet detection and a limit of detection of 2 ng/ml.
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Venlafaxine and Breast-Feeding

VICTORIA HENDRICK, M.D., LORI ALTSHULER, M.D., AMY WERTHEIMER, B.A., and WILLIAM A. DUNN, M.S., F.T.S.-A.B.F.T., T.C.(N.R.C.C.)
Los Angeles, Calif.

Am J Psychiatry 158:2089-2090, December 2001

(A venlafaxine Magyarországon Efectin és Velaxin néven van forgalomban.)

To the Editor: Clinicians treating new mothers for depression require information about the safety of antidepressants if used while the mothers are breast-feeding. In contrast to extensive data on the use of selective serotonin reuptake inhibitor (SSRI) antidepressants by women who are breast-feeding (1–4), we know of only one small case series (N=3) on the use of venlafaxine by breast-feeding mothers (5). In this report, the estimated mean dose the infants received from breast milk was 7.6% of the maternal weight-adjusted dose.
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Rapid disappearance of zaleplon from breast milk after oral administration to lactating women

M Darwish, PT Martin, WH Cevallos, S Tse, S Wheeler, and SM Troy

The Journal of Clinical Pharmacology, 1999; 39:670-674

(A zaleplon Magyarországon Sonata néven van forgalomban.)

Five lactating mothers were administered the therapeutic dose of zaleplon (10 mg) orally in an open-label, single-dose, pharmacokinetic study. Plasma and breast milk were sampled through 8 hours after dose administration for subsequent determinations of zaleplon and its major, though inactive, plasma metabolite 5-oxo-zaleplon. Zaleplon concentrations peaked in plasma and milk approximately 1 hour after dosing and then disappeared rapidly. The mean terminal half-life was slightly greater than 1 hour. Milk concentrations “mirrored” plasma concentrations closely with no discernible delay between peak times.
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Excretion of loratadine in human breast milk

J Hilbert, E Radwanski, MB Affrime, G Perentesis, S Symchowicz, and N Zampaglione

The Journal of Clinical Pharmacology, 1988; 28:234-239

(A loratadine Magyarországon Clarinase, Claritine, Erolin, Flonidan, Lorano, Loratadin, Roletra neveken van forgalomban.)

The excretion of loratadine, a new nonsedating antihistamine, into human breast milk was studied in six lactating nonpregnant volunteers. Each volunteer received one 40-mg loratadine capsule. Milk and blood were collected before and at specified times (to 48 hours) after dosing. Plasma and milk loratadine concentrations were determined by a specific radioimmunoassay, and those of an active but minor metabolite, descarboethoxyloratadine, by high performance liquid chromatography (HPLC). Breast milk concentration-time curves of both loratadine and descarboethoxyloratadine paralleled the plasma concentration-time curves.
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BREASTFEEDING AND MATERNAL MEDICATION – Recommendations for Drugs in the Eleventh WHO Model List of Essential Drugs

Often there is a need to decide whether a mother who is breastfeeding and who needs treatment with drugs can take the necessary medication and still continue breastfeeding safely. There are very few kinds of treatment during which breastfeeding is absolutely contraindicated. However, there are some drugs which a mother may need to take which sometimes cause side-effects in the baby. The summary box “Breastfeeding and Mother`s Medication” on page 3 provides a preliminary guide. This document gives more detailed information about specific drugs from the Eleventh Model List of Essential Drugs.
World Health Organization, 2003

A teljes dokumentum a WHO oldalán található.
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Drug Excretion Into Breast Milk – Overview

Breastfeeding is the optimal form of infant feeding for the first months of an infant’s life, and the majority of healthy women initiate breastfeeding after the birth of their infant. However, women on medication may default to formula feeding or not taking their drug therapy for fear of exposing their infant to the medication through the breast milk.
Advanced Drug Delivery Reviews Vol. 55 No. 5 2003. pp 617-627

Az absztrakt itt található.
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Pooled Analysis of Antidepressant Levels in Lactating Mothers, Breast Milk, and Nursing Infants

Alicia M. Weissman, M.D., Barcey T. Levy, Ph.D., M.D., Arthur J. Hartz, M.D., Ph.D., Suzanne Bentler, M.S., Micca Donohue, M.D., Vicki L. Ellingrod, Pharm.D., and Katherine L. Wisner, M.D., M.S.

Am J Psychiatry 161:1066-1078, June 2004

OBJECTIVE: The available data on antidepressant levels in nursing infants were analyzed in order to calculate average infant drug levels and determine what factors influence plasma drug levels in breast-feeding infants of mothers treated with antidepressants.

METHOD: Electronic searches of MEDLINE, PreMEDLINE, Current Contents, Biological Abstracts, and PsycINFO from 1966 through July 2002 followed by bibliographic searches identified 67 relevant studies (two unpublished). By consensus the authors identified 57 studies of maternal plasma, breast milk, and/or infant plasma antidepressant levels from nursing mother-infant pairs, measured by liquid chromatography.
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Medications and Lactation: What PNPs Need to Know

Jennifer M. Marks, BS; Diane L. Spatz, PhD, RNC

J Pediatr Health Care 17(6):311-317, 2003.

Abstract and Introduction

Abstract
The current rise in breastfeeding rates coincides with a continuously expanding prescription medication market. Now more than ever, pediatric nurse practitioners (PNP) are responsible for ordering and consulting on maternal medications during lactation. PNPs are obligated to determine the safety of medications by critically reviewing recommendations that are based on recent clinical research. However, sources vary widely in the relevance of their information. Ideally, comprehensive research-based recommendations about medications and lactation should be based on the pharmacokinetics of drugs in the maternal system, the oral bioavailability of the medication to the infant, and the infant evaluation.
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